P3 Fab Anti-Human GPIbα (MVI-1003)

01 Description

P3 monovalent Fab retains the sub-nanomolar affinity for GpIbα of the IgG from which it is derived. The labelled version of P3 Fab can be used to track human platelets in whole blood microscopy experiments without the complication of platelet clumping, and/or off-target effects typically mediated by the Fc portion of an IgG. Moreover, it can be used for a correct and precise determination of the number of GPIbα molecules on platelet surface.

02 Specifications

Clone & Isotope

Mouse IgG1, k

Reactivity

Human

Immunogen

Human Platelets

Storage Buffer

PBS, pH 7.4

Storage Conditions

Cold room for <6 months, -20°C for longer storage. Avoid freezing and thawing cycles.

Datasheet

03 Prices

Standard Format

CAT.# Size Price ($)
MVI-1003-0.1-UN 0.1 mg 120.00
MVI-1003-0.1-LA 0.1 mg 150.00
MVI-1003-0.25-UN 0.25 mg 250.00
MVI-1003-0.25-LA 0.25 mg 312.50
MVI-1003-0.5-UN 0.5 mg 415.00
MVI-1003-0.5-LA 0.5 mg 518.75

04 References

Yin H, Stojanovic-Terpo A, Xu W, Corken A, Zakharov A, Qian F, Pavlovic S, Krbanjevic A, Lyubimov AV, Wang ZJ, Ware J, Du X. Role for platelet glycoprotein Ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortality. Arteriosclerosis, thrombosis, and vascular biology. 2013;33(11):2529-37. Epub 2013/09/21. doi: 10.1161/atvbaha.113.302339. PubMed PMID: 24051142; PMCID: PMC4043446.

Gong H, Shen B, Flevaris P, Chow C, Lam SC, Voyno-Yasenetskaya TA, Kozasa T, Du X. G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin “outside-in” signaling. Science (New York, NY). 2010;327(5963):340-3. Epub 2010/01/16. doi: 10.1126/science.1174779. PubMed PMID: 20075254; PMCID: PMC2842917.

Tomer A, Scharf RE, McMillan R, Ruggeri ZM, Harker LA. Bernard-Soulier syndrome: quantitative characterization of megakaryocytes and platelets by flow cytometric and platelet kinetic measurements. European journal of haematology. 1994;52(4):193-200. Epub 1994/04/01. PubMed PMID: 8005229.

Handa M, Titani K, Holland LZ, Roberts JR, Ruggeri ZM. The von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. Characterization by monoclonal antibodies and partial amino acid sequence analysis of proteolytic fragments. The Journal of biological chemistry. 1986;261(27):12579-85. Epub 1986/09/25. PubMed PMID: 2943738.

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