The P5 monoclonal antibody specifically binds to human GP IIb/IIIa (CD41/CD61 complex), also known as integrin αIIBβ3. GPIIb/IIIa is the most highly-expressed megakaryocyte- and platelet-specific heterodimeric integrin complex. It plays an instrumental role in thrombosis and hemostasis by mediating platelet adhesion and activation upon engagement of different ligands, including fibrinogen, fibrin, von Willebrand Factor (VWF), and fibronectin. The pivotal role of GPIIb/IIIa to platelet function and vascular integrity is demonstrated by severe bleeding disorders caused by functional impairment or absence of GPIIb/IIIa in patients with Glanzmann thrombasthenia. The P5 monoclonal antibody is able to specifically block VWF interaction with GPIIb/IIIa without inhibiting platelet aggregation induced by ADP, collagen, and α-thrombin or fibrinogen binding to GPIIb/IIIa. Available unlabeled and labeled.
Clone & Isotope