P5 – Anti-Human αΙΙbβ3 mAb (MVI-1008)

01 Description

The P5 monoclonal antibody specifically binds to human GP IIb/IIIa (CD41/CD61 complex), also known as integrin αIIBβ3. GPIIb/IIIa is the most highly-expressed megakaryocyte- and platelet-specific heterodimeric integrin complex. It plays an instrumental role in thrombosis and hemostasis by mediating platelet adhesion and activation upon engagement of different ligands, including fibrinogen, fibrin, von Willebrand Factor (VWF), and fibronectin. The pivotal role of GPIIb/IIIa to platelet function and vascular integrity is demonstrated by severe bleeding disorders caused by functional impairment or absence of GPIIb/IIIa in patients with Glanzmann thrombasthenia. The P5 monoclonal antibody is able to specifically block VWF interaction with GPIIb/IIIa without inhibiting platelet aggregation induced by ADP, collagen, and α-thrombin or fibrinogen binding to GPIIb/IIIa.  Available unlabeled and labeled.

02 Specifications

Clone & Isotope

Mouse IgG1, k

Reactivity

Human

Immunogen

Human platelets

Storage Buffer

PBS, pH 7.4

Storage Conditions

Cold room for <6 months, -20°C for longer storage. Avoid freezing and thawing cycles.

Datasheet

03 Prices

Standard Format

CAT.# Size Price ($)
MVI-1008-0.1-UN 0.1 mg 80.00
MVI-1008-0.1-LA 0.1 mg 100.00
MVI-1008-0.25-UN 0.25 mg 200.00
MVI-1008-0.25-LA 0.25 mg 250.00
MVI-1008-0.5-UN 0.5 mg 350.00
MVI-1008-0.5-LA 0.5 mg 437.50

04 References

05 Order Inquiry Form

Please contact us for information on availability and payment options.

  • This site uses cookies to improve your experience and to meet your requests. The information gathered with this form only aims to satisfy your request. We don’t share this information with anyone. To enable this policy, select the following check box, otherwise we will not be able to proceed.
  • (*) This field is mandatory.
  • We will respond to your request within 24 hours.