P3 – Anti-Human GPIbα mAb (MVI-1002)

01 Description

P3 IgG reacts with the NH2-terminal region of human GpIbα which is also known as CD42b. Expressed as component of a hetero-oligomeric membrane complex together with GpIbβ, GPIX, and GPV, GPIbα binds proteins involved in inflammation, thrombosis, and hemostasis, of which the best characterized are von Willebrand Factor (VWF) and α-thrombin (FIIa). P3 IgG has subnanomolar affinity for GpIbα and does not inhibit FIIa nor VWF binding.  Available labeled and unlabeled.

02 Specifications

Clone & Isotope

Mouse IgG1, k

Reactivity

Human

Immunogen

Human Platelets

Storage Buffer

PBS, pH 7.4

Storage Conditions

Cold room for <6 months, -20°C for longer storage. Avoid freezing and thawing cycles.

Datasheet

03 Prices

Standard Format

CAT.# Size Price ($)
MVI-1002-0.1-UN 0.1 mg 80.00
MVI-1002-0.1-LA 0.1 mg 100.00
MVI-1002-0.25-UN 0.25 mg 200.00
MVI-1002-0.25-LA 0.25 mg 250.00
MVI-1002-0.5-UN 0.5 mg 350.00
MVI-1002-0.5-LA 0.5 mg 437.50

04 References

Handa M, Titani K, Holland LZ, Roberts JR, Ruggeri ZM. The von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. Characterization by monoclonal antibodies and partial amino acid sequence analysis of proteolytic fragments. The Journal of biological chemistry. 1986;261(27):12579-85. Epub 1986/09/25. PubMed PMID: 2943738.

Gong H, Shen B, Flevaris P, Chow C, Lam SC, Voyno-Yasenetskaya TA, Kozasa T, Du X. G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin “outside-in” signaling. Science (New York, NY). 2010;327(5963):340-3. Epub 2010/01/16. doi: 10.1126/science.1174779. PubMed PMID: 20075254; PMCID: PMC2842917.

Yin H, Stojanovic-Terpo A, Xu W, Corken A, Zakharov A, Qian F, Pavlovic S, Krbanjevic A, Lyubimov AV, Wang ZJ, Ware J, Du X. Role for platelet glycoprotein Ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortality. Arteriosclerosis, thrombosis, and vascular biology. 2013;33(11):2529-37. Epub 2013/09/21. doi: 10.1161/atvbaha.113.302339. PubMed PMID: 24051142; PMCID: PMC4043446.

Tomer A, Scharf RE, McMillan R, Ruggeri ZM, Harker LA. Bernard-Soulier syndrome: quantitative characterization of megakaryocytes and platelets by flow cytometric and platelet kinetic measurements. European journal of haematology. 1994;52(4):193-200. Epub 1994/04/01. PubMed PMID: 8005229.

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