5A7 – Anti-Mouse GPIbα mAb (MVI-1001)

01 Description

The 5A7 clone binds mouse GPIbα, and when injected in vivo, it completely depletes circulating platelets for 3 days with as little as 1 μg/g mouse weight. Moreover, 5A7 works very well to phenotype mouse GpIbα on mouse platelets or megakaryocytes. GPIbα, also known as CD42b, is a 145kD glycoprotein expressed on the surface of platelets and megakaryocytes in a hetero-oligomeric membrane complex composed of GpIbβ, GPIX, and GPV. This platelet membrane complex binds to proteins involved in inflammation, thrombosis, and hemostasis, of which the best characterized are von Willebrand Factor (VWF) and α-thrombin (FIIa).  Available unlabeled and labeled.

02 Specifications

Clone & Isotope

Rat IgG1, k

Reactivity

Mouse (C57BL/6, FVB, 129, BALB/c, NZB, DBA/1, DBA/2, SWR tested thus far).

Immunogen

Mouse Glycoprotein Ibα

Storage Buffer

PBS, pH 7.4, filtered 0.22 μm for sterility.

Storage Conditions

Cold room for <6 months, -20°C for longer storage.  Avoid freezing and thawing cycles.

Datasheet

03 Prices

Standard Format

CAT.# Size Price ($)
MVI-1001-0.5-UN 0.5 mg 350.00
MVI-1001-0.5-LA 0.5 mg 437.50
MVI-1001-1.0-UN 1.0 mg 650.00
MVI-1001-1.0-LA 1.0 mg 812.50
MVI-1001-5.0-UN 5.0 mg 3,000.00
MVI-1001-5.0-LA 5.0 mg 3,750.00

04 References

Kanaji T, Vo MN, Kanaji S, Zarpellon A, Shapiro R, Morodomi Y, Yuzuriha A, Eto K, Belani R, Do MH, Yang XL, Ruggeri ZM, Schimmel P. Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia. Proceedings of the National Academy of Sciences of the United States of America. 2018;115(35):E8228-e35. Epub 2018/08/15. doi: 10.1073/pnas.1807000115. PubMed PMID: 30104364; PMCID: PMC6126720.

Kossmann S, Lagrange J, Jäckel S, Jurk K, Ehlken M, Schönfelder T, Weihert Y, Knorr M, Brandt M, Xia N, Li H, Daiber A, Oelze M, Reinhardt C, Lackner K, Gruber A, Monia B, Karbach SH, Walter U, Ruggeri ZM, Renné T, Ruf W, Münzel T, Wenzel P. Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension. Science Translational Medicine. 2017;9(375).

Koltsova EK, Sundd P, Zarpellon A, Ouyang H, Mikulski Z, Zampolli A, Ruggeri ZM, Ley K. Genetic deletion of platelet glycoprotein Ib alpha but not its extracellular domain protects from atherosclerosis. Thrombosis and haemostasis. 2014;112(6):1252-63. Epub 2014/08/12. doi: 10.1160/th14-02-0130. PubMed PMID: 25104056; PMCID: PMC4429870.

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