CONTRACT RESEARCH SERVICES

Apply our expertise to your product development through MERU VasImmune’s Contract Research Organization (CRO) services. We will assist you with designing preclinical development strategies, utilizing our knowledge base and models ranging from in vitro cell-based assays to unique in vivo mouse models. We offer a variety of CRO services including:

In Vitro

  • Real-time binding kinetics of mAbs or ligand interaction with platelet receptors
  • Characterization of antiplatelet drug inhibitory potential by agonist-induced aggregation
  • Coming soon: Shear-induced aggregation

Ex Vivo

  • Design, execution, and interpretation of thrombogenesis studies under selected flow conditions, with visualization of platelets, platelet aggregates and fibrin deposition

In Vivo

  • Ferric chloride (FeCl3)- or laser-induced models of arterial and venous thrombosis
  • Unique, humanized animal models
    » Human GPIbα/human VWF A1 domain interaction
    » Coming soon: Thrombin/human hPAR1 interaction